Apr 22, 2007
Please what new developments are there as per drugs and treatment that might bring final solution in the near future. thanks.
| Response from Dr. Frascino
I've been accused (and rightfully so) of being the most optimistic person on the planet, but to think that there is a "final solution" (i.e. cure) in the "near future" is being overly optimistic, even for me! What I can do is briefly update you on what's coming next down the HIV/AIDS drug development pipeline, OK? In the mid-1990s HAART (highly active antiretroviral therapy) came into widespread use with the availability of potent new drugs, particularly protease inhibitors (PI's). PI's in combination with our reverse transcriptase inhibitor drugs (RTIs) dramatically decreased HIV/AIDS morbidity and mortality.
Now, after a decade, two new classes of anti-HIV drugs are hitting the market integrase inhibitors and CCR5 antagonists!
Integrase inhibitors stop the enzyme (integrase) that allows the virus into the host T-cell's DNA. If that process is stopped, then HIV can't replicate!
CCR5 antagonists block the co-receptor that is necessary for HIV to invade a cell. The good news is that these agents should be effective for folks who have developed resistance to the older drugs (PIs and RTIs). So far the side-effect profile for these new drugs has been mild, but we don't know if there will be any long-term toxicities.
Finally, I should mention a potential breakthrough in HIV vaccine development. One of the biggest roadblocks to an effective HIV vaccine has been the uncanny ability of HIV to constantly mutate, thereby making the vaccine less effective or even useless. Earlier this year, researchers at NIAID (National Institute for Allergy and Infectious Diseases) found a protein on HIV's surface that doesn't mutate. So theoretically we might be able to make a vaccine that stimulates antibodies against this protein, which, in theory at least, could neutralize the virus! Research is underway! Stay tuned to The Body. As always we'll keep you informed as the information evolves!
Get Email Notifications When This Forum Updates or Subscribe With RSS
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.