|hiv 2 and meds (HIV-2)
Dec 13, 2006
hello Dr Franscino,i have hiv 2 how will i know my viral loads and when is the best time to start the meds? do you have any information on how to manage hiv 2?
| Response from Dr. Frascino
Hello, You will need the help of an experienced HIV specialist to help you with those decisions.
Here's what we know about HIV-2. Compared to HIV-1, HIV-2 is less transmissible (five- to eight-fold less efficient than HIV-1 in early-stage disease and it is rarely the cause of vertical transmission). HIV-2 infection is associated with lower viral loads and a slower rate of both CD4 cell decline and clinical progression. Nevertheless, mortality rates for HIV-1 and HIV-2 infections are similar when adjusted for viral load. Some patients may be coinfected with both HIV-1 and HIV-2. There are currently no treatment guidelines for HIV-2; however, most HIV specialists suggest the same clinical, viral load and CD4 count criteria used for HIV-1 be used for HIV-2 as well. HIV-2 is not susceptible to non-nucleoside reverse transcriptase inhibitors (NNRTIs), like Sustiva and Viramune. HIV-2 may also have multiple protease inhibitor-associated resistance mutations. There are no commercially available viral load assays or resistance profiles for HIV-2, although these tests can be performed by some specialty laboratories. Your HIV specialist will need to arrange for this for you.
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