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gene therapy

Nov 12, 2006

I just read in the newspaper that phase 1 testing of a new gene therapy has concluded with wonderful results. The study involved people who were drug resistant and were running out of options. Basically they introduced some other vaccine into the person's body and over the nine months of the trial run, immune systems were strenghtened and hiv count decreased! This study only involved 5 people but i believe they all had good results, and now they are going to start more testing with people on meds. This sounds wonderful, doesn't it? Do you think the virus will be able to mutate to counter this gene therapy? The article said the big advantage was that it only required one dose instead of daily medications. So tell me your thoughts im interested to hear what you think about this new study. Hey we finnally got the house and senate back now we can focus on 08. We need to find someone good, that americans will back, i Like obama. hooray, the democrats finnally got the majority, now we just need to take the rest of the those gay bashing republicans and some of the democrats out. Hope to hear back from you on this

Response from Dr. Frascino


I addressed the results of this very preliminary study involving gene therapy "antisense" techniques recently. See below.

Regarding the elections, the voters finally realized the hypocrisy of phony swaggering, blustering and bellicosity without competency and accountability! If they had been reading this forum they would have realized all this six years ago. Better late than never.

Stay well.

Dr. Bob

Fighting HIV with HIV? Nov 11, 2006

Hello Sexy,

Is this true?

For the lazy bums:

WASHINGTON (Reuters) - An AIDS virus genetically engineered to fight other AIDS viruses worked better than expected, suppressing the virus and renewing the immune systems of a few patients, researchers reported on Monday.

The study involved just five people, and such an approach needs years more study, they cautioned -- but the surprising results offer new hope both for the field of gene therapy and for treating the fatal and incurable AIDS virus.


Response from Dr. Frascino


Yes, this very intriguing paper was published in a well respected peer-reviewed medical journal this week (Proceedings of the National Academy of Sciences). It was a "safety and feasibility" study, not an efficacy study, and consequently involved only five patients. It involved a gene therapy procedure called "antisense," which involves genetically altering HIV to make it unharmful ("nonpathogenic"). CD4 cells were removed from the five test subjects. Those cells were then infected with the genetically altered virus and reinfused back into the patients. Four of the five test subjects showed some degree of immune restoration. It is important to note this is a very preliminary report and even if it does work, it will take a number of years to develop and will require monitoring the patients for short- and long-term complications. Is antisense gene therapy anywhere near ready for prime time? Nope! Is it cause for optimism? Absofrickinlutely! Stay tuned to The Body. We'll keep you updated as this potential new therapy evolves.

Dr. Bob

Your wise advice...
I'm scared

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