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pep doseage confusion Indinavir 2 or 3 times day?

Aug 24, 2005

Been prescribed PEP Combivir and Indinavir both at 2 doses per day.

However have read here and at WHO website that Indinavir should be taken 3 times daily.

Currently taking 2 times. Up dosage to three times day?

many, many thanks.

Response from Dr. Frascino


The correct dose of indinavir is 800 mg every eight hours in a fasting state (one hour before or two hours after a meal). You should also drink at least six eight-ounce glasses of water per day (48 oz) to prevent indinavir-associated kidney stones. Twice per day dosing is possible, but only when indinavir is combined with ritonavir (either 400 mg ritonavir plus 400 mg indinavir or 100 mg ritonavir plus 800 mg indinavir).

There are a number of non-indinavir containing PEP regimens that can be taken twice per day.

Good luck!

Dr. Bob

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