Repeatedly reactive EIAs
Jul 29, 2005
Dear Dr. Frascino: I have a client who was tested twice in 2002 with these results: HIV1 repeatedly reactive; HIV2 neg; HIV1 Western Blot uninterpretable; IFA neg. Client was tested again about 2 months ago at a different lab. Results: HIV1-2 repeatedly reactive; HIV1-2 WB neg. Client's blood type is AB+. Pt is of Asian descent. Only apparent risk is heterosexual unprotected sex. What's causing this and what's the appropriate testing protocol in this situation? Please reply. By the way, I think you have a great website. Thanks!
Response from Dr. Frascino
Your patient is HIV negative.
The exact cause of persistent indeterminate results (formally defined as positive ELISA and a single band on WB) is not completely understood. In this type of situation, I would recommend a non-antibody dependent assay to clarify the serological results. Specifically, I would suggest the qualitative plasma HIV DNA polymerase chain reaction. It has demonstrated sensitivity in the 97%-98% range and its specificity is 98%.
Get Email Notifications When This Forum Updates or Subscribe With RSS
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.