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Missed Dose & PEP

Dec 27, 2004

I started PEP (1 Sustiva at night and 2 Trivizir at 12 hours each) 15 days ago for high risk sexual exposure. Last night, I forgot to take my Sustiva and Trivizir combo. This morning I did not immediately take the Sustiva because I needed to be at work and I cannot funtion on the stuff. I did immediately take the Trivizir. Did I ruin my PEP!?!

Response from Dr. Frascino


Nope! Although it's obviously preferable to take all the doses, missing one Sustiva will not ruin PEP. In fact, a four-drug regimen Trizivir (Retrovir, Epivir and abacavir) plus Sustiva is quite aggressive for PEP. Many physicians use only a two- or at the most, a three-drug combo. Many avoid Sustiva for PEP mainly due to the central nervous system effects. So at any rate, you can relax. No harm done. OK?

Happy Holidays.

Dr. Bob

Dangerous Oral sex ofter shave ---
unprotected sex with my hiv + partner

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