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PEP termination

Sep 2, 2002

If after an occupational exposure (needle stick injury)PEP has been started. However, after 7 days the DNA PCR comes negative, should/can the PEP be stopped?

Response from Mr. Kull

If possible, post-exposure prophylaxis should not be discontinued until the entire regimen is completed. The CDC recommends a 28 day/4 week treatment with an approved antiretroviral regimen. Treatment should not be stopped based on testing performed during treatment. After treatment is completed, antibody testing should be conducted periodically for up to six months following exposure.

See the CDC's publication on PEP for healthcare workers.


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