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Adherence to HAART and Resistance (9/11)
Sep 18, 2000

Dr. Holodniy,

You know, now that you ask me, I'm not sure where I heard about what you referred to as the "90 minute rule" with protease inhibitors. I think it may have come up during a discussion with my doctor regarding the importance of not missing doses. Regardless of this aside, my question is whether there are any data regarding how stringently one must conform to the q12h and qD dosing in my regimen (sustiva, 3tc, d4t) to minimize the development of resistance. Will being a couple of hours off here and there make a discernible difference?

Thank you.

Response from Dr. Holodniy

To my knowledge there has not been a study.

MH


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