Aug 5, 1999
mark, 1)if you show resistance to certain nukes such as AZT and 3TC, can you still use them in the future or currently with an nnrti or pi? 2)isn't it true that in order for a resistant strain to appear, hiv must mutate into a cell that goes around all three drugs that you are using? 3)so if this mutated cell/strain does prevail/occur, wouldn't it be resistant to all the drugs you are on? 4)or am i wrong in that hiv needs only to mutate around one or two barriers (such as 2 nuke barriers or 1 nuke and 1 nnrti) so that viral load will go high again (above detection)? Lastly, i always here about people being resistant (or at least slighty) to many nukes but still use them successfully in haart regimens. 5)does this mean that nuke resistant isn't as important to resistance to nnrti's and pi's? I am lead to believe that the main goal is to avoid resistance to nnrti's and pi's and that resistance to nukes aren't that great a loss? Please answer my 5 questions so that i better understand what will occur after i start treatment. I plan on going on sustiva, ddi, abacavir, and hydroxea; i heard it's a solid combo and saves the pi's - any comments to this combo?
Response from Dr. Holodniy
1. It would be unlikely they will have long term effectiveness. 2. Not necessarily. At least at the level we can measure, you might be resistant to 2 of 3 or 2 of 4 of the meds you are on. 3. See 2. 4. See 2. 5. One mutation can cause class resistance to NNRTI. One or two mutations can cause significant PI cross resistance. Although there are some class NRTI mutations, they are rare. Thus, it is much rarer for broad NRTI resistance to develop. Love the regimen. MH
Drug Holiday-Wild Type Virus
Picking Your Brain!
- Ache In Testicles After Unprotected Sex Without Ejaculation Worried I Have HIV
- Itchy Red Spots After Sensual Massage Sign Of HIV AIDS
- Tingling In Fingers After Touching Vaginal Secretions Worried I Have HIV
- White Spots After Deep Kissing Worried I Have HIV
- Can Keflex Treat Chlamydia?
- Can Vaginal Discharge Cause Sores?
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.