|line probe assay
Jun 6, 2001
Dear Dr., I heard mentioned that a lineprobe assay is a resistance test that can be sued when vl<1,000 copies. Is this true? Is it a genotype or phenotype test? And are any commercial labs running this test? How can I get it done?Secondly,I've heard that you can send your blood to a univ to see how virulent a strain you have.Is this a good idea?and how do you do this?Sincerely,Luke
Response from Dr. Little
The line probe assay can be done with relatively low levels of virus, but at present is less clinically useful than the available genotype and phenotype tests because it only detects drug resistance mutations in one class of drugs (the nucleosides - AZT,ddI,3TC,d4T,ABC, ddC). Although the makers of the line probe are working on modifications which would detect all of the well described drug resistance mutations, I would guess that the most useful test for use in management of your antiretrovirals would still be a genotype or phenotype. Some of the commercially available genotype and phenotype tests can now be used down to a viral load close to 200 copies. I would discuss the need for such a test and perhaps even find out from the laboratory what their lower limit is for submitting a specimen (in terms of the viral load) and then order whichever test seems like it will most likely give you an answer.
In terms of determining whether you have a virulent strain - there are many tests available on a research basis which do address this sort of thing, but they are generally not used in clinical practice, because they do not change treatment management. If you are interested in contributing to the field of research, you may have local opportunities worth pursuing, but I would not advise that you seek out this test otherwise, since it is not clear that it would be particularly helpful. The rate at which your T cells fall or remain stable over time will give you the same information.
WHAT IS A NADIR?
Food for thought...mild HIV ?
- Can I Get Hiv If I Have Bacterial Vaginosis?
- Vaginal Symptoms Of Hiv
- When Is The Best Time For Hiv Test?
- Can Somebody Get Infected With Hiv Through Drinking Infected Blood?
- How Often After Infected Does An Hiv Test Show You Been Infected?
- If You Have An Open Cut Or Wound Can You Get Hiv?
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.