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Drug Delivery
Jun 14, 2007

With all the concern over taking meds as prescribed (same time everyday). Why hasn't there been a "patch" type drug delivery system been developed like they have for so many other medications? This would alleviate the problem and anxiety of missed meds and above all help thwart viral resistance.

Response from Dr. Sherer

This is a good suggestion, but not all forms of drugs lend themselves to delivery through the skin. There is certainly a lot of attention to the optimal form of antiretroviral drugs by the pharmaceutical industry, but to date there has not been an attempt to use percutaneous delivery forms, to my knowledge.

Still, our ability to use most regimens once or twice daily with only 1-7 pills daily still represents a dramatic advance over the early HAART era from 1996 to 2000.

And I would point out that patches are subject to the same requirements as once or twice daily pills, i.e. the patient has to remember to put them on at the same time every day. Even with patches, the problems and anxieties associated with missed doses would still remain.

Accuracy of resistance tests?

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