The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App 
Professionals >> Visit The Body PROThe Body en Espanol
Ask the Experts About

HIV Drug ResistanceHIV Drug Resistance
Rollover images to visit our other forums!
  • Email Email
  • Glossary Glossary

Does Mutations mean Resistant?
Mar 30, 2006

Does having mutations mean that you are resistant or does it mean resistant to a certain level? My Geno type showed 3 mutations but my Doc said he was not worried about the three mutations. Does this mean I am resistant or resistant to a certain level? If so what does the Doc to to compensate for those mutation? Thank you

Response from Dr. Sherer

Good question, and one to write down and take to your doctor for your next visit, as he or she is the best one to answer your qeustion based on the specific mutations that you have, the regimen that you are taking, your recent adherence and viral load and CD4 cell counts, adverse drugs reactions, and a lot of other information that I lack.

Still, based on your doctor's answer, I am guessing that your genotype showed real mutations, but ones that are not associated (neither individually or as a group of 3) with decreased susceptibility to any regimen or single drug. These are often called polymorphisms or secondary mutations. I would caution you and your doctor that while we have seen little evidence to date that these polymorphisms contribute to phenotypic reduced susceptibility to a drug or a regimen, or to regimen failure, we are still learning about their role.

So your question is a good one because your have mutations which are not associated with resistance (apparently), showing that not all mutations lead to resistance.

If you did have resistance, your doctor would choose a new regimen which he would expect to have suppressive activity against the resistant virus.

In the meantime, your job remains to keep up the best possible adherence to your regimen, and to ask the same question to your doctor with these comments as well.

NRTI choice after phenotype
two readings of Viral load plus 700

  • Email Email
  • Glossary Glossary



This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint