|Twice the dose on PEP Help!
Aug 8, 2005
Hi Doctor, Im from Bangalore, India, after a risky encounter I met with a nice general practioner doctor who put me on PEP ( initiated 14.5 hours post exposure) with odivir - DDL + 3TC + EVF at double the prescribed the dose, after taking this for a week, I was also added D4T - stavir again at 2 times the recommended dose, is it ok can I drop to a regular dose without any fear of resistance? Or should I complete the 28 days at this double dose, and, the WHO accredited pecialists tah t Iwished to see here, one was not in town the other was not seeing patients that day, shame! I Many thanks in advance.
Response from Dr. Sherer
Yes, you should return to the normal recommended dose and complete the 28 day course. In addition, for PEP I would only recommend at most a three drug regimen, unless you have some very specific information about the source and the nature of the virus that he or she is carrying, e.g. you or your physician knew that this individual was resistant to DDI, for example - which I doubt in your case.
Whenever a mistaken dose is discovered, one should immediately notify your physician and discuss the steps that should be taken next.
I appreciate that in your case, your ability to do this was limited, and your doctor was apparently the one who prescribe the drugs in error.
There would not be an increase in the risk of resistance from an inappropriately high dose of ART. Rather, the risk is of unnecessary toxicity from the higher than expected drug levels. As you have not mentioned these, you may not have suffered from this error. It would also be appropriate to have your blood work repeated as well to look for toxicity, for example of the liver.
Is treatment failure inevitable?
HIV Rape Case
- Is Vaginal Fluid Safe?
- Receiving Oral Sex Worried I Have HIV
- Diarrhea After Licking Genital Worried I Have HIV
- Dizziness After Anal Sex Without Condom Does It Mean I Have HIV
- Itchy Scrotum After Touching Vaginal Fluid Sign Of HIV AIDS
- Thrush After Oral Sex With No Protection Does It Mean I Have HIV
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.