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novel class of anti-retrovirals
Apr 3, 2005

hello, i was just wondering about th new compounds of the Tibotec, the belgian company manufacturing what appear to be anti-retrovirals with a very high resistance barrier.I read that multiple strains of HIV were screened over 28 days without any resistance emergence.However resistance is possible.can u tell me how likely it for resistance to occur with the new compounds ( TMC 114. 125 and 278) about to hit the market in the next few years?

Response from Dr. Sherer

These drugs are actually new members of the known classes of drugs - the non-nucleosides (NNRTIs)and the protease inhibitors.

As you note, among their important characteristics are activity against most, but not all, viruses that are resistant to the current agents in the class.

Unfortunately, its a near-certainy that these drugs also will be ultimately susceptible to new mutants and drug resistant. We have yet to find an antiretroviral that is 'resistance-proof'. The virus has many characteristics that make this highly likely, including the frequency of mutations, the high rate of viral replication, and the presence of sequestered sites like the central nervous system and the gonads.


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