|novel class of anti-retrovirals
Apr 3, 2005
hello, i was just wondering about th new compounds of the Tibotec, the belgian company manufacturing what appear to be anti-retrovirals with a very high resistance barrier.I read that multiple strains of HIV were screened over 28 days without any resistance emergence.However resistance is possible.can u tell me how likely it for resistance to occur with the new compounds ( TMC 114. 125 and 278) about to hit the market in the next few years?
Response from Dr. Sherer
As you note, among their important characteristics are activity against most, but not all, viruses that are resistant to the current agents in the class.
Unfortunately, its a near-certainy that these drugs also will be ultimately susceptible to new mutants and drug resistant. We have yet to find an antiretroviral that is 'resistance-proof'. The virus has many characteristics that make this highly likely, including the frequency of mutations, the high rate of viral replication, and the presence of sequestered sites like the central nervous system and the gonads.
VERY WORRIED ABOUT RESISTANCE
- Highly Active Anti-Retroviral Therapy (HAART)
- What Kind Of Sexually Transmitted Infections Does Doxycycline Monohydrate Treat?
- Are Purple Bumps On Side Of Mouth Cheeks A Sign Of Hiv?
- Atripla And Long Term Viral Suppression
- Can HIV Positive People Join The National Guard?
- Can HIV Virus Enter Through Ears?
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.