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cross-resistance BETWEEN classes?
Oct 27, 2004

Hi,

Is it possible to have an NRTI resistance mutation that's also resistant to PIs or NNRTIs? Can mutations cross over entire classes, or do they only cross over to other meds within one specific class?

Thank you! Concerned

Response from Dr. Sherer

At present, there is no evidence of cross resistance outside of a single class. Thus our concerns for cross resistance are limited to drugs of the same class, and sequencing of regimens is dominated by options for second and third line drugs in the NRTI and PI class, since the NNRTIs to date have complete cross-resistance, and can only be used once.


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