The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App 
Professionals >> Visit The Body PROThe Body en Espanol
Ask the Experts About

HIV Drug ResistanceHIV Drug Resistance
Rollover images to visit our other forums!
  • Email Email
  • Glossary Glossary

Med switch: resistance?
Sep 7, 2004

Positive for about a year and on combivir/sustiva for most of that time with stable, good results (VL=ND, CD4+=700; 38%). Some low grade AZT anemia making me and my doc think about truvada/sustiva. If we go in this direction would it be best to include AZT for a few days during my first few days as truvada kicks in to limit potential for AZT resistance? Thanks!

Response from Dr. Sherer

There is no reason to think that an alternate strategy is needed for a single drug substitution of zidovudine with tenofovir in your case. The NRTIs do not require days to 'kick in'; they are promptly absorbed, enter the cell nuclei, and are active. This is also true of tenofovir. You can safely stop the combivir in the evening and start the truvada, i.e. co-formulated emtricitabine (FTC) and tenofovir (TDF) the following morning.

CRF Literature
1 yr. anniversary

  • Email Email
  • Glossary Glossary



This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint