Advertisement
The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol
Read Now: TheBodyPRO.com Covers AIDS 2014
   
Ask the Experts About

HIV Drug ResistanceHIV Drug Resistance
           
Rollover images to visit our other forums!
  
  • Email Email
  • Glossary Glossary


Risk of blooming with a resistant strain?
May 24, 2004

Dr., My numbers all point to being a long-term nonprogressor. My CD4 count ranges between between 560 and 900, depending on the time of day taken, which I have been told is unusual, and my CD8s range between 200-346. My percentages remain stable, 47-50% CD4s and 21% CD8s. My percentage is 2.18. My viral load has remained undetectable <50 with no blips. I have never been on meds, and have been fully positive for 8-9 months. What is the likelihood of my having to go on meds in the future? Am I likely to eventually bloom? I read that low viral replication rate could be an indication that I have a highly mutated protease inhibitor resistant strain, is that true? Have you ever seen that with somebody in my situation, when they changed to detectable? My doctors said that my low CD8 count is an indicator of very low replication, and possibly none, and that my body isnt detecting antigen. Im worried I might have a little bomb of virus that may go off at any time, and change my good luck. Does that happen with people in my situation often? Thanks, Worried in NYC

Response from Dr. Sherer

Unfortunately, the real number of long term non-progressors has been very low, <1% of all infections. On the other hand, there are many who have progressed very slowly, i.e. have not required therapy over a period of 10-15 years. Perhaps it would be wiser to set your hopes on a long period without treatment, which is very good news in and of itself, rather than setting your hopes too high.

It is still early in the known span of your infection to be sure, but I agree that you appear to have a very stable infection at this point. As there are many important sub-populations of CD8, I would not interpret high, low, or changing CD8 counts quite so simply. We are not aware of all of the causes for such changes, nor is it well established what their implications are for the natural history of HIV infection.

And, as you suggest, it may be that your virus is 'less fit', as an explanation for the level being below detection, but other explanations are also possible. If and when your virus level becomes detectable, you and your physician will perform a resistance test and partly answer that question.


Previous
Genotypic vs. phenotypic tests
Next
COnfused re resistance tests - conflicting results

  
  • Email Email
  • Glossary Glossary


 
 
Advertisement




Q&A TERMS OF USE

This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint

Advertisement