Advertisement
The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol
Read Now: Expert Opinions on HIV Cure Research
   
Ask the Experts About

HIV Drug ResistanceHIV Drug Resistance
           
Rollover images to visit our other forums!
  
  • Email Email
  • Glossary Glossary


Question on Resistance
Feb 5, 2004

Dear Doctors,

I have a question on the Kaletra/Combivir regimen. I was diagnosed last year with a 13 cd4 count and over 300,000 viral load. I was immediately put on the above regimen. It's been exactly one year since I've started this regimen and was wondering how long does it take for resistance to build to any of the medications on this particular HAART combo???? Also, do you think this was a wise combo to start on given my initial diagnosis. Thank you in advance for answering my quesiton!

Response from Dr. Sherer

Yes, I think this was a good initial choice for you. Kaletra and Combivir are listed among the preferred regimens for initial therapy in the HHS Guidelines.

In a study of a similar regimen of LPV/r (Kaletra) and D4T and 3TC (rather than AZT + 3TC, which is in combivir), patients like you with initial CD4 cell counts below 50 and viral loads above 100,000 did as well as those with higher CD4 cell counts and lower viral loads.

You could probably answer your own question better than I regarding how well you are doing. What has happened to your CD4 cell count and your viral loadin the last year? How do you feel? The answers to these questions are more important than the range of possible responses that I could describe.

Regarding how long it takes resistance to develop, that depends on a long list of factors, such as how regularly you take your medications, whether there was drug resistance at the time you started your medications, how well you have tolerated the regimen, and other factors. One advantage of the regimen you are on is that resistance to the protease class has not been seen when LPV/r is used in the initial regimen, and resistance to other drugs in the class occur infrequently.


Previous
magic johnson style hiv
Next
Drug Resistance Development Possible?

  
  • Email Email
  • Glossary Glossary


 
 
Advertisement




Q&A TERMS OF USE

This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint

Advertisement