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What PI to start with??
Nov 22, 2002


What PI do you recommend starting with, if resistence is not a factor in choosing one. Is there a better first option due to resistent patterns?


Response from Dr. Little

This may depends a bit upon the individual (i.e. is there a pre-existing elevation of blood lipids such as cholesterol) - but if not, I generally use indinavir plus ritonavir, or amprenavir plus ritonavir, or Kaletra. This represents only my personal opinion though and not an agreed upon consensus among providers. All are twice daily regimens with related but slightly different side effect profiles. I would not tend to use the indinavir regimen on someone who does not regularly consume sufficient water to minimize the risk of kidney stones.

Why worry about low NRTI load?
RE: may not be blip.

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