Ginkgo

Jul 17, 2012

Im thinking of taking ginkgo to improve my memory and I take Norvir, Viread, Epzicom and Reyataz

Response from Mr. Vergel

There was one report of a potential interaction between Ginkgo and Efavirenz (Sustiva, part of Atripla) Don't take Ginkgo biloba with efavirenz

However, a study found that Ginkgo may not present an interaction problem with Norvir boosted lopinavir (Kaletra) and potentially other Norvir boosted protease inhibitors:

Effect of Ginkgo biloba extract on lopinavir, midazolam and fexofenadine pharmacokinetics in healthy subjects

Ginkgo is one of those supplements that has shown mixed results in different studies for improvements in cognitive function. There have been no studies in HIV. A review of studies done until 2006 found inconclusive results:

Ginkgo biloba for cognitive impairment and dementia

The Charter study found that those with mild cognitive impairment tended to have lower CD4 nadirs (the lowest CD4 value measured) than those without impairment. So, preserving your CD4 cells may be the best way that you can slow down cognitive decline. CHARTER Study Finds Neurocognitive Impairment Still Common in ART Era, Linked to Lowest CD4 Cell Count

Conclusive studies in HIV- adults have shown that cognitive function can be improved by proper sleep, exercise, learning a new language, hormone replacement, cognitive training techniques and medication.

Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment

Testosterone and cognitive function: current clinical evidence of a relationship

The Impact of Insomnia on Cognitive Functioning in Older Adults

Medication related interventions are also being studied in HIV: Can an Alzheimer's Drug Help HIV+ People with Cognitive Dysfunction?

I hope this information helps you decide!

Nelson Vergel