The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App 
Professionals >> Visit The Body PROThe Body en Espanol
Ask the Experts About

Nutrition and ExerciseNutrition and Exercise
Rollover images to visit our other forums!
Recent AnswersAsk a Question
  • Email Email
  • Glossary Glossary

Is there any advantage from switching from Atripla to QUAD?

May 21, 2012

I just heard the FDA may approve the QUAD pill. Since this is a newer pill, it may be better than Atripla? Should I switch?

Response from Mr. Vergel

QUAD is a one pill taken once a day containing an integrase inhibitor (elvitegravir), a booster (cobicistat), and two nucleoside analogs (tenofovir- Viread and emtricitabine- Emtriva). It has been reviewed positively by a FDA panel for a potential approval in the near future. It will be the third one pill, once a day regimen in the market after Atripla and Endurant.

Many questions remain about QUAD. Studies have shown decreases in creatinine clearance (kidney function). It has not been studied in many people with CD4 cells under 200 cells/ml and women. We do not know all its interactions with other drugs used in HIV.

If you are doing well on Atripla without fatigue, anxiety, sleep problems, depression, I would not switch. If you are having side effects, talk to your doctor about the other two DHHS guidelines recommended "first line" regimens: Isentress plus Truvada and Boosted Reyataz or Prezista plus Truvada.

I should remind people that just because a drug is newer, it does not necessarily mean it is better.

Nelson Vergel

HIV, Atripla and Vitamin D supplementation
HIV positive Bodybuilding and questions about Steroid Use

  • Email Email
  • Glossary Glossary

 Get Email Notifications When This Forum Updates or Subscribe With RSS



This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint