Advertisement
The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol
Read Now: TheBodyPRO.com Covers AIDS 2014
   
Ask the Experts About

Nutrition and ExerciseNutrition and Exercise
           
Rollover images to visit our other forums!
Recent AnswersAsk a Question
  
  • Email Email
  • Glossary Glossary


What should I start with?
Aug 21, 2011

Nelson, I just heard that there is a new pill called Complera that one can take instead of Atripla. I have not started HIV medications yet but my T cells are 300 and my viral load is climbing (Now 75,000). I am afraid of Atripla since my friends tell me that it causes nightmares and depression. Should I ask my doctor for Complera instead? Thanks for all you do to digest information for all of us, bud!

Response from Mr. Vergel

I want everyone to be aware of this when thinking about starting Complera (rilpivirine plus Truvada in one pill)

While rilipivirine (RPV) demonstrated non-inferiority to Sustiva (efavirenz- EFV) in phase 3 studies, it was noted that for participants with higher pre-treatment HIV RNA (> 100,000 copies/mL), virologic failure occurred more frequently in those randomized to receive RPV than Sustiva. Furthermore, subjects failing RPV were more likely to fail with genotypic resistance to other NNRTIs (EFV, etravirine [ETR], and nevirapine [NVP]) and to have resistance to their prescribed NRTIs.

Drug discontinuations because of adverse effects were more common with EFV than RPV. The frequency of depressive disorders and discontinuations due to depressive disorders were similar between the two arms, whereas dizziness, abnormal dreams, rash and hyperlipidemia were less frequent with RPV, compared to EFV.

RPV must be administered with a meal (preferably high fat). Its oral bioavailability can be significantly reduced in the presence of acid lowering agents. RPV should be used with caution with antacids and H2-receptor antagonists. RPV use with proton-pump inhibitors is contraindicated.

Also, keep in mind that nausea was more common in the Complera arm than in the Atripla arm.

Talk to your doctor about all of this information.

Nelson



Previous
Low free test level.
Next
email or netaddress

  
  • Email Email
  • Glossary Glossary

 Get Email Notifications When This Forum Updates or Subscribe With RSS


 
Advertisement



Q&A TERMS OF USE

This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint

Advertisement