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Breakthrough in HIV Research?
Mar 29, 2010

I recently saw a post on Yahoo from a blogger at Redorbit claiming researchers have had a substantial breakthrough coming from the Imperial College of London and Harvard. The research suggests the enzyme integrase structure has been grown with a "crystal" and will lead to improved drugs and drug resistance. Is there anyplace you can point me in to read more about this?

Response from Mr. Vergel

This is what they concluded: "Our findings will allow the generation of reliable HIV-1 integrase and integrase strand inhibitor pharmacophore models, which will be invaluable for the development of next-generation strand-transfer inhibitors."

So, this discovery will probably make it easier to develop better integrase inhibitors. We have one approved now (raltegravir), one up for approval (elvitegravir) and one in phase 2 research (GSK572). But whoever comes up with a truly innovative once-a-day integrase inhibitor that works against integrase resistant HIV strains which does not have any side effects and interactions, will conquer the HIV medication market, specially if only one other medication is needed with it, which could be coformulated in one pill once a day. This new formulation will take over the Atripla and the upcoming QUAD pill market. But this is years away but certainly very possible!

Nelson



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