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Can Fish Oils Interact with Kaletra?
Dec 2, 2008

I am taking fish oil capsules to lower triglycerides that went up with Kaletra.

Is there a danger for this supplemen to lower Kaletra in my blood?

Thank you

Jose

Response from Mr. Vergel

Dear Jose

A study done in HIV positive patients with a median triglyclerides (TG) of 662-697 mg/ml (John G. Gerber et al, Fish Oil and Fenofibrate for the Treatment of Hypertriglyceridemia in HIV-infected Subjects on Antiretroviral Therapy: Results of ACTG A5186. J Acquir Immune Defic Syndr. 2008;47(4):459-4660) gave patients 3000 miligrams of Omega 3 capsules twice a day with or without Tricor (fenofibrate- a fibrate medication that lowers triglycerides). Fish oil reduced TG levels by a median of 283 mg/dL (46%), fenofibrate reduced them by 367 mg/dL (58%), and combination therapy reduced them by 65.5%. Combination therapy achieved TG levels of less than 200 mg/dL in 22.7% subjects (200 mg or less is the recommended target for TG). Omega 3 capsules had no effect on Kaletra blood levels or CD4 cells.

Nelson



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