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Imodium and Kaletra

Apr 19, 2008

Nelson, I am currently taking Kaletra plus Truvada and my T cells have gone up from 60 to 320 in 3 years while my viral load is undectable, but my gut has always been a problem (diarrhea and bloating at least twice a week). I am not losing weight but it is kind of inconvenient and I seem to be getting hooked on Imodium. Are there any studies going on to study options for this? Or should I switch meds?


Response from Mr. Vergel

Dear Doug,

Diarrhea is one of the most devasting issues that impacts quality of life in HIV. I am glad your numbers are good on a combo that has been shown to be extremely effective at controlling HIV. I assume that your doctor ruled out any parasitic infection or other pathogens.

There are some people who would rather switch meds than to treat and deal with medication-induced diarrhea. The new Kaletra formulation seems to cause less diarrhea than the old one, and Truvada does not seem to cause GI problems on its own. Some doctors have switched patients from Kaletra to boosted Reyataz or Isentress to minimize the problem. But many doctors would rather make this the last option to deal with the problem.

There are supplements like calcium carbonate, glutamine and acidophilus that may help some (calcium should not be taken with meds though).

There is currently a study of a plant extract (Crofelemer) that is enrolling if you want to try that out so that you do not have to switch medications. Go to

Good luck and keep us informed!


Diet and lipohypertrophy
general lipoatrophy

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