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new less toxic meds in 2004?
May 25, 2004

Hola Nelson!

Buenas Tardes! I was wondering what less toxic meds are closing the door for approval in this year of 2004? You have to admit that it is nerve wrecking how no new novel agents have been approved this year when last year had quite a few, wouldn't you say! Lo Siento, yo practico mi espanol con ti. Buenas Suerte! Vaya con Dios! Muchas Buena Salud!

Hasta Luego,

Pierre Nueva Jersey

Response from Mr. Vergel

No new drugs will be approved in 2004. But there are many in the pipeline. Tipranavir, a new protease inhibitor that may work against multi-drug resistance virus, will be approved in 2005. The main side effects are diarrhea and some liver enzyme increases. There is also another protease coming through called TMC-114 and a non-nuke called TMC 125 (studies can be found at clinicaltrials.gov). But so far, most drugs have some sort of side effects. The new oral entry inhibitors seem to be pretty safe so far, but we will not know until the phase II dosing and safety studies are finished.

Things are looking up. But we do not have a cure in the horizon yet, and 90% of the 42 million people living with HIV in the world have no treatment.

Nelson



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