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wasting hypothesis
Mar 20, 2004

What if wasting is caused by HIV actually infecting the muscle cells the way it infects the cd4 cells, and then killing them off?

It would make sense, because the same way subsets if cd4s are killed off and thought to never return regardless of rising cd4s after therapy, after much wasting, even anabolics won't return all the muscle tissue back to the way it was before.

Response from Mr. Vergel

Wasting is multi factorial and not only linked to viral replication and infection. People start eating less, they have diarrhea and malabsorption, their energy expenditure goes up, and some medications may worsen fat and muscle loss. I am one of those who belives 100% that wasting syndrome can be completely reversed after a patient is stabilized. Anabolic steroids and growth hormone can do wonders in replenishing lean body mass to baseline or above baseline levels.

Nelson



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