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B-complex & Omega-3
Jun 1, 2003

Hi Nelson,

1. Would the intake of high potency B-complex (say, nicotinamide (niacin) 50 mg, B1 50 mg, B6 50 mg....) be harmful to the body ? Is 50 mg of niacin be efficient to reduce LDL and triglyceride ?

2. Per another expert in the forum, Omega-3 1000 fatty acid is a weak anti-cytokine material. Thus, is it really efficient to reduce triglyceride ?

3. if one stop the intake the b-complex of omega 3 fish oil (after the LDL shows improvement), would the LDL or triglyceride rise back to the high level afterward ?

Thanks for your comment.

Response from Mr. Vergel

All of them are water soluble B vitamins. Your body gets rid off the excess in your urine, so do not worry about overdosing at 50 mg/day.

There was a study on Niacin to see the effects on lipids in people with HIV. A prescription grade niacin called Niaspan was initiated at 500mg. The dose was increased to 1,000 mg after 2 wks and subsequently titrated upwards by 500 mg every 4 wks to a maximum of 2,000 mg per day to achieve NCEP goals. Subjects received Niaspan therapy for 14 wks. Fasting lipid profiles were evaluated every 2 wks during the first month and then monthly. Research study investigators concluded that Niaspan significantly decreased triglycerides and total cholesterol levels, but did not normalize them. Insulin sensitivity worsened. There were no increases in liver enzymes.

You can get omega-3's oils by eating more fish, including salmon, tuna, sardines, anchovies, mackerel, rainbow trout, and herring. Non HIV studies show a decrease in tumor necrosis factor and IL-1, a catabolic cytokine associated with wasting, with optimal intake of the omega-3 fatty acids that are contained in fish oils. Two HIV studies showed a non statistical significant difference (but a positive trend) in decreasing truglycerides. There are several non HIV studies that are emerging with positive data on the heart protecting effects of Omega 3 oils.

Another effective way to decrease triglycerides is to execise and lower your sugar and simple carb intake. Carnitine supplementation at 2000-3000 mg/day has also shown to help.

Like with everything else, triglycerides will tend to return to baseline if you stop the supplements (unless you change medications that can increase triglycerides like protease inhibitors or Zerit)



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