Which SNRI increases dopamine the most?
Feb 3, 2013
Which SNRI out of Effexor and Cymbalta increases dopamine the most and has the most/best effect on dopamine? Also, are there any tables or research on this anywhere?
Response from Dr. Fawcett
Thanks for writing. SNRIs (serotonin-norepinephrine reuptake inhibitors) are so-called dual-action drugs that are used to treat major depression and other mood disorders. They are called dual-action because they work on those two specific neurotransmitters.
There is no simple answer to your question. First, the effectiveness of these drugs stems from the impact on both norepinephrine and dopamine, not just the latter. Second, the impact on dopamine reuptake can be dependent on dosage. Effexor, for example, has little effect on dopamine reuptake at lower doses but it increases at higher doses.
Speak with your physician to select the best medication for your symptoms.
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