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Single Dose of Ativan (lorazepam) OK to take with Atripla?

Mar 3, 2011

Prior to starting on HIV meds, I had taken Ativan previously to help with dental appointments. I have now been on Atripla for over 3 years. I am about to go to the dentist next week for some potentially major dental work. I told my dentist about the prior use of Ativan, and he said he prefers to use Halcion. I saw on the Atripla Package Insert where it specifically says do not take Halcion (triazolam) or Versed (midazolam) while taking Atripla. But it doesn't mention Ativan or even say 'or any other medications in the same class' as the other two. So my question is, are there any known side effects/contraindications for Atripla and Ativan? This would just be a one-time, day-of-procedure usage. Should I be okay to take it? Or am I gonna have to tough it out with Novacaine alone?

Response from Dr. Fawcett

Both Ativan and Halcion are benzodiazepines, which have sedative and sleep-inducing effects. The blood levels of benzodiazepines can reach dangerously high levels when combined with Atripla. With certain benzodiazepines such as Versed (midazolam -used in surgery) and triazolam (for sleep), the reaction can be fatal. Both Ativan and Halcion are listed as contraindicated when used with Atripla. Discuss this with your primary care physician as well as dentist novacaine may be your best bet.

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