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homo vanillic acid

Jun 12, 2006

Dear Dr. Horwath, I'm a HIV pos male, seroconverted one year ago. Immune system is still adapting, but quite ok (CD4 580, 28%). Was on sipralexa (escitalopram) for about 6 months, have stopped the sipralexa after gradually lowering the dose over 2 months. My HIV physician is now addressing a hypertension problem (cardiac echo shows thickening of muscles, have been hypertensive for about 2 years based on those measurements). Heart/kidney scans are ok, slight thickening of heart muscle, no elevated catecholamines in urine, excess homovanillinic acid in urine. I'm on a mild dosage ACE inhibitor now. Might these elevated homovanillinic acid titers be caused by recent sipralexa usage? As a biochemist, i know the homovanillinic acid is a dopamine metabolite. I've never taken drugs (the recreational ones), so never toyed with my neurotransmittors :)... Now dopamine disorders are aplenty and linked to spooky stuff such as schizofrenic behaviour... Woud you care to enlighten me? Yours, European biochemist

Response from Dr. Horwath

No, using escitalopram would not elevate your homovanillic acid titers. And more importantly, escitalopram is not associated with elevated blood pressure.

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