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HIV dementia
Nov 22, 2005

I would like to know if there is a place where I can find statistics of the use of AZT to treat Dementia related to AIDS and how well it's treatment.

Response from Dr. Horwath

There is one placebo-controlled study of AZT for the treatment of AIDS dementia complex, published in 1993 by Sidtis and colleagues. In this study, AZT at high doses (2,000 mg/day) was associated with significant improvement in neuropsychological tests, when compared to a lower dose (1,000 mg/day) and to placebo.

This study was done before HAART was available. AZT is no longer used as a single agent, and it is no longer given at such high doses because of the toxic side effects. This type of treatment is not feasible now, but the study does tell us that AZT can benefit people with AIDS dementia complex at high doses.

More recent studies also show that effective HAART regimens also are of great benefit for the symptoms of AIDS dementia complex, as well as greatly decreasing morbidity and mortality due to AIDS in general.



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