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antidepressent for someone with HIV

May 20, 2005

What would you think is the best antidepresent for a person with hiv and questionable PML?


Response from Dr. Horwath

First, it should be clarified that an antidepressant would not treat the symptoms of PML. However, if you're asking about the treatment of depression in someone with AIDS and PML, then Celexa would be a very good choice. Other antidepressants that are safe and effective in persons with AIDS would include Zoloft and Lexapro. These drugs have the advantage of being well tolerated and having very little in the way of drug interactions with antiretroviral and other medications.

Of these 3 drugs, Zoloft has been shown to be effective in several double-blind, placebo controlled clinical studies of depressed persons with HIV infection.

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