SSRIs vs Triclycic antidepressants
Feb 19, 2005
I read a recent study and the investigators found that SSRIs may be effective and better tolerated than tricyclic antidepressants in HIV-positive adults. SSRIs did not appear to affect CD4+ cell counts. They said that if drug-drug interactions are a concern, sertraline (Zoloft), citalopram (Celexa), and possibly escitalopram (Lexapro) may be considered.
Is this really new? Were these drugs not used in HIV positive people before. What's the big deal about this study?
Reference J Caballero and M C Nahata. Use of selective serotonin-reuptake inhibitors in the treatment of depression in adults with HIV. Annals of Pharmacotherapy 39(1): 141-145. January 2005.
Response from Dr. Horwath
No, this is not new. But this article sounds like a review, and probably isn't intended to present new findings.
Both SSRI's and tricyclic antidepressants have been used and studied for depression in people with HIV infection. Both are effective, and when used properly, both are safe. Tricyclics are associated with the risk of cardiac arhythmias if the blood levels are too high. Drug interactions can elevate blood levels. Some HIV drugs, like ritonavir, can cause to such interactions. All things considered, the SSRI's are considered somewhat safer and better tolerated than tricyclics. However, when used with attention to the potential adverse effects, tricyclics are quite safe and effective. Among the SSRI's, sertraline, citalopram and escitalopram are less associated with drug interactions than paroxetine (Paxil) and fluoxetine (Prozac).
Get Email Notifications When This Forum Updates or Subscribe With RSS
- Oral Ulcers After Swallowing Cum Sign Of HIV AIDS
- Painful Ejaculation After Anal Sex Without Condom Does It Mean I Have HIV
- Swollen Lymph Nodes After Masturbation Worried I Have HIV
- Tingling Lips After Breast Sucking Worried I Have HIV
- White Bumps On Penis After Inverted Condom Worried I Have HIV
- Can I Get Genital Herpes If I Used A Condom?
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.