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HAART and Zoloft

Sep 3, 2004

Hello, I am a 44 year old Poz male diagnosed just last month. My CD4 count is 100 and my Viral load is 450,000. Everything else is fine so far, and my HIV specialist is very optimistic about my treatment. I have been on 100mg of Zoloft for over ten years for depression, and it has worked well for me. I have just started on Combivir and Sustiva,(one week now). I feel ok , aside from a lack of energy. My question is, are there any issues regarding Zoloft and HAART that i should be aware of?


Response from Dr. Horwath

Zoloft is an excellent choice as an antidepressant along with HAART. It has very little potential for drug interactions, and is well tolerated along with other medications, including HAART.

You might want to observe for changes in your mood, sleep and dreams. Chages in mood, sleep and vivid or unusual dreams are common side effects of Sustiva. They tend to occur early on in treatment (during the first several weeks) and are sometimes transient. If these adverse effects occur and are severe or persistent, then you may need to consult with your psychiatrist to help manage these side effects.

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