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st. john's wort

Aug 11, 2003

Does St. John's Worth interfere with antiretrovirals?

Response from Dr. Horwath

Yes, St. John's Wort is known to lower antiretroviral medication levels. This is a potentially life threatening drug interaction because it may lead to failure of the antiretrovirals and/or development of viral resistance.

St. John's Wort is a weak and generally ineffective antideprssant, which is marketed as an herbal remedy or nutrtional supplement. Controlled studies have shown that it is not very effective compared to other antidepressant medications, which are both more effective and safer when used together with antiretrovirals.

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