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HIV and Inhibition of Antigen Presentation

May 3, 2003

Dear Doctor, Please dont ignore this. This is regarding your response that antidepressants have no immunosupressive affects. I understand that the usage of antidepressants results in an increased amout of interleukien 10 (IL 10 ) in the body.

And IL 10 downregulates antiviral responses by inhibiting ANTIGEN Presentation (MHC Class II ). T cells stimulates B cells to produce antibodies when it is presented with the anigens by Antigen Presenting Cells. How does the body produce antibodies when the antigen presentation is inhibited by the increase in amount of IL 10 ?.Pls answer my concern

Response from Dr. Henry

I would be surprised if that effect is clinically meaningful. I have cared for hundreds of HIV+ patients on antidepressants and have seen no evidence of a negative effect. In fact, treating depression often improves adherence which leads to a better response to antiretroviral therapy. KH

Psych. meds... long term?
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