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Mood Changes with Drug Changes?

Mar 6, 2001

Hi, Michael, First time I've logged on. I'm overwhelmed by the information, but I'm a kid in a candy store so here goes. I'm male, 37, HIV+ for 14 years, TCells 980, VL 1750 and in great shape. I've covered AZT, to D-drugs to Protease Inhibitors. Three weeks ago I switched off D4T, DDI, Norvir, Invirase and Acyclovir (total of 29 pills a day for 2 Yrs.)to 3TC, Viramune, Ziagen (new Dr. Thank God!). The last 2 years were hell. Depression-like, mood swings, memory loss, intence migranes, low grade headdaches, etc. During the past 3 weeks I first experienced increased anger, violent outbursts, sleeplessness, crying, etc., but changed to feeling good for once, light and revived. Could the past meds have created that hell and could the switch produce such behavior? Have you heard of this with anyone else or am I just a male, 37, in good shape, 14 years lucky and just nuts? Thanks.

Response from Mr. Shernoff

Over the years I have had patients report their own version of the emotional and mental side effects of various anti viral medications, especially Norvir. Each person has his or her own idiosyncratic reation to these drugs. So it is a definite possibility that your own various moods were related to the various drugs you were on and then stopped taking. Michael Shernoff, MSW

worried about HIV mom with mental illness
Will I be able to continue as normal

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