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Blood Brain Barrier and Viramune
Feb 7, 2003

I have neuropathy and some forgetfullness and slight cognitive problems. I've worried about my brain's health. I'm on a structured interuption right now but will go back to Viramune and Combivir. Does Viramune cross the blood/brain barrier? This may influence my decision about which med to return to. Thank you.

Response from Dr. Horwath

Yes, Viramune (nevirapine) very effectively crosses the blood-brain barrier. It is an excellent choice of anti-retroviral medication in patients with cognitive problems due to AIDS. Because of its robust entry into the central nervous system, some physicians have suggested that it is indicated in patients with HIV-associated dementia or minor cognitive motor disorder. You should discuss your decision with your doctor, since other factors may also play an important role in choosing an antiretroviral regimen.



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