Please Note: Due to volume considerations, not all questions can be answered. Questions most likely to be answered will be those of general interest to a broad group of visitors to this forum. Questions pertaining to a specific case; requests for diagnosis, medical advice, or second opinion; or requests for opinions about untested alternative therapies will generally not be answered.
The participation of Dr. Ewald Horwath in this Forum is made possible by Boehringer Ingelheim.
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CAN U TAKE TRAZADONE WITH ANTIVIRALS
Apr 28, 2008
TRAZADONE WITH ANTIVIRAL MEDICATIONS FOR AIDS
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Response from Dr. Horwath
Trazodone is an antidepressant that is metabolized by an enzyme called CYP450 3A4. This enzyme is inhibited by some protease inhibitors, especially ritonavir. This means that taking these 2 drugs together could result in higher than expected levels of trazodone.
When using these drugs together, it may require adjusting the dose of trazodone. However, trazodone is mostly used in low doses for sleep, and with this type of use, it is unlikely that a drug interaction would result in any problems. Typically, when used for sleep, trazodone is given in doses of 50-100 mg at bedtime. When used together with ritonavir, it may result in being more sedating than usual. In that case, reducing the dose to 25-50 mg at bedtime would be appropriate.
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