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Contemplating Treatment Interuption

Oct 10, 2001

I have been on the same three drugs (3-TC/Zerit/Crixivan) for nearly 5 years. Viral load has remained undetectable and CD-4 stabalized between 500-700. Twice I have stopped treatment for one month; both times after an increase in VL and decrease in T-cells, I returned to undetectable with T-cell rebound after 8 weeks. I think I am going to start a one month off two months on routine. What do you think? Tom LA

Response from Dr. Boyle

Well, I think that is risky. There is currently very limited data regarding that strategy, and what exists shows that that treatment interruption schedule is likely to lead to the development of resistance, especially if you are on drugs with low genetic barriers such as Epivir (lamivudine, 3TC). I would not recommend that you pursue that strategy at this time. If you are burning out on the regimen you are currently taking, an interruption with careful monitoring or changing to a simpler regimen would be a better strategy.

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