|Are Tcells depleted by non-OI's?
Jun 26, 1998
I understand that T cells are the big guns of the immune system but am wondering if they are depleted by non-opportunistic infections such as Sinus infections or ear infections or abcessed teeth etc. and how these more common infections affect the way HIV drugs supress the virus. Thank you
| Response from Dr. Currier
The types of infections you refer to are all bacterial infections and they are common in HIV infection. HIV, the virus is thought to infect T cells and kill them. These other infections do not directly infect T cells, but when people have these infections they may indirectly cause HIV to replicate which will cause further decline in T cells. So indirectly you could say that these infections can deplete T cells. There is some evidence that recurrent bacterial infections can cause more rapid progression of HIV.
I do not know of any way that these infections would interfere with the way drugs work on the virus.
Hope this helps.
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