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Protease Inhibitors Work for Some Not For Others

Jul 22, 1997

Why do some protease inhibitors seem to suppress viral loads to nearly 0 in some patients and can not in other patients?

Response from Dr. Cohen

The most common reasons for protease inhibitor failure in my experience are:

Noncompliance: the drugs are taken erratically, with missed or delayed doses Lack of effective combination therapy: the protease inhibitors are taken in combination with drugs to which resistance has already developed. Extensive pre-treatment (a variation on #2): the patient has taken so many other antiretroviral agents in the past that there are no good combination options available.

In addition, some patients may have such a high viral load to begin with that the drug combination is not powerful enough to reduce the viral load to undetectable levels. Finally, sometimes the therapy fails and we can't come up with a good reason.

Protesae Inhibitors and Alcohol

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