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CD4
May 23, 2001

If you decide to stop treatment, are you bound loose cd4 quicker if youve had lower levels before, more that if you have always been around same level? Thank you

Response from Dr. Pavia

Take everything we say about treatment interuption with a grain of salt, since this is a relatively new area. Having said that, the best predictors of how fast your CD4 count will drop if you stop therapy are probably how fast you were dropping before therapy, and how high your viral load is after stopping. I just saw a summary of a study (but not the study itself) that said that people who had had a very low CD4 count at some point dropped faster after a treatment interuption than those who had never had low CD4 counts. This all pre-supposes that your immune system is not better at controlling HIV after treatment than it was before, and that is a $64 question.

Hope this helps ATP



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