AZT VS RILPIVIRINE
Nov 30, 2017
Hello Dr. Young,
I would like to know in witch ways RILPIVIRINE is superior/better/less toxic compared to AZT.
Response from Dr. Young
Hello and thanks for posting.
This is an unusual comparison of medications. AZT (zidovudine) is a nucleoside RT inhibitor, while rilpivirine (Edurant, part of Odefsey and Juluca) is a non-nucleoside RT inhibitor. The two classes of drugs are, generally speaking, not interchangable.
Once a key treatment for people living with HIV, AZT is now rarely used- primarily because it's not very well tolerated (common side effects include nausea, vomiting, headaches and muscle aches) and causes significant toxicity (anemia, lipodystrophy).
Rilpivirine is one of the medications in the combination regimen/pills Complera, Odefsey and the new Juluca. It's quite well tolerated and side effects are uncommon, though rash and mood changes have been reported. Rilpivirine has to be taken with food and has a number of significant drug-drug interactions.
I hope that's helpful, BY
Get Email Notifications When This Forum Updates or Subscribe With RSS
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.