Advertisement
The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App 
Professionals >> Visit The Body PROThe Body en Espanol
   
Ask the Experts About

Choosing Your MedsChoosing Your Meds
         
Rollover images to visit our other forums!
Recent AnswersAsk a Question
  
  • Email Email
  • Glossary Glossary


chosing the best available regimen

Sep 1, 2017

I ALWAYS like to be on the best latest regimen.,,, ( lucky to have insurance that pays ok) Doing well on triumeq... ( <20 cd4 780 37%, stable for many years) Started d4t/zerit/viracept in 1995? made changes as times changed, .. atripla. stribild, tivicay and ??? and now triumeq.. I read a post from dr joel gallant from late 2016 that said when he talks with hiv specialists. the regimen that they would take if they needed one , is tivicay with f/taf. thoughts on this regimen.. ? to go from one pill at bedtime ( triumeq) to 2 pills at bedtime is not an issue for me.. and as we age.. every side effect should be considered.. I'm 57.. thanks.

Response from Dr. Young

Hello and thanks for posting.

Today's HIV treatments are a vast improvement over earlier regimens, and many of today's HIV integrase ihhibitor regimens have shown superiority over previously vaulted regimens, like Atripla.

Dolutegravir-containing regimens such as your dolutegravir/abacavir/3TC (Triumeq) and Dr. Gallant's "favorite" dolutegravir + FTC/TAF (Descovy) are 5 of the just 6 recommended combinations in current US DHHS treatment guidelines.. Since you're already on Triumeq, we can assume that you've already passed the main requirement for Trimeq use, namely the HLA B5701 genetic test. There are differences among each, but I'd have a difficult time giving you an evidence-based reason why Tivicay+Descovy is better than Triumeq. The core agent in both is dolutegravir, offering excellent tolerability/potency/safety, drug resistance profile, and lack of drug-drug interactions.

If anything, I'd be following the developing story of the use of dolutegravir two drug regimens (either with rilpivirine or 3TC) with interest. Both new combos portend greater differences than the Triumeq or Tivicay+Descovy switch that you've listed, and clinical trials results so far have been strongly affirmative. Additionally, long-acting once-a-month injectable two drug regimens with a dolutegravir cousin (cabotegravir) are moving along.

So, if you were my patient and already successful on a DHHS-recommended regimen, I'd likely not strongly advocate switching, unless the switch offered you clear cut improvement.

I hope that's helpful, BY



Previous
Question about PreP as ART?
Next
Is it safe to switch from Nevirapin to Eflavirenz

  
  • Email Email
  • Glossary Glossary

 Get Email Notifications When This Forum Updates or Subscribe With RSS


 
Advertisement



Q&A TERMS OF USE

This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint

Advertisement