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Change of Medication- Liver

Apr 30, 2017

Hello Doc...I write from Argentina,,sorry for my english...My doc changed my meds because lipids problems... I was with Kaletra+ Raltegravir and now Darunavir + Raltegravir. (Now two months). I am resistent to all INNTI. There are a problem with muy labs,,,,ALT (liver) up from 28U/L (03/02/17) to 73 U/L (20/04/2017). AST up from 24 (03/02/2017) to 34 U/L (03/02/2017). Alkaline Phosphatase without changes (55 U/L). As you see, there is a significative increse of ALT...Is that normal with the med change until the body get accustomed to darunavir? Thank you!!!!

Response from Dr. Holodniy

I am not concerned. Although you don't indicate whether any other medications or over-the-counter medications or products were taken, that increase is within a 2-fold increase for ALT and could certainly be associated with the change to darunavir.



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