Dec 30, 2015
Dearest Dr Young,
I know that there are several factors involved but, as a general rule, what percentage of people that start HAART with one of the current 5 US-recommended combinations will develop obvious fat or other physical changes in their first 10-15 years of treatment? Happy new year to all of us!
Warm regards, John
Response from Dr. Young
Hello and thanks for posting.
In large, well-controlled clinical trials of current treatments, new onset lipodystrophy is very rare. One of the best, long-term reports on lipo with integrase inhibitors comes from the analysis of raltegravir (Isentress). In this report of people in the STARTMRK study , there were no reported cases of lipodystrophy among those who started raltegravir, and only ~1% among those who started efavirenz (Atripla).
As you note, people who had more risks, extensive disease and treatment history (in the BENCHMRK study), about 5% developed lipodystrophy.
Hope that's helpful, BY
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