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Switching back 2 Old Regimen
Dec 10, 2015

I have been on truvada and use tress for the past 3 years with undetectable viral loads. My doctor recently convinced me to switch to truvada and tivacay. I don't like the way tivacay makes me feel. Is it possible to switch back to my old regimen without any problems?

Response from Dr. Young

Hello and thanks for posting.

One quick thought- if you're not already, try taking your Tivicay on an empty stomach. Food increases the absorption of Tivicay by ~20%, and if you're the rare person who's experiencing side effects, this might help.

OK, that said, yes, you can readily switch back to the twice-daily Isentress without problems. Indeed, a large clinical trial, called ACTG 5257 compared Isentress twice-daily to two different (and excellent) once-daily boosted PIs, and the Isentress regimen turned out to be superior- despite being twice daily. So, if twice a day wasn't a problem for you, there's no need to worry about the Isentress. Indeed, for people already taking a twice-daily medication, it could be a very reasonable, and well tolerated option.

Hope that helps, BY

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