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cryptococcal Meningitis (HIV Negative)
Oct 28, 2015

My uncle is suffering from cryptococcal Meningitis, From last two weeks, We are giving the Liposomal Amphotericin B, Daily from from last two weeks, there is no improvement i the patient he not taking any thing orally(food), Is this disease that much critical,Doctors saying there no hope but is only suffering from Headache, All other organs are normal. could you please suggest what we can do . we are from Hyderabad(INDIA)

Response from Dr. Young

Hello and thank you for posting from Hyderabad.

So sorry to learn about your uncle. Cryptococcal meningitis, while a common AIDS-related complication also affects HIV-negative people. It's a very serious condition and requires weeks of potent antifungal medications.

In accordance with the current Infectious Disease Society of America guidelines, your uncle appears to be getting excellent medications. Improvement can be arduously slow (at least in my experience in caring for HIV+ patients with crypto). In some patients, repeated spinal taps are recommended to assess and reduce increased pressure around the brain.

You also mention that he's not eating- in such patients, intravenous or gastric feeding may be necessary.

Sadly, if you uncle's doctors assessment of his condition is hopeless, then a transition to palliative or hospice care should be discussed.

I hope that's helpful. BY

Dumiva, Atazor and Norvir
atripla and clarithramycin

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